Immunogenicity of Four Plasmodium falciparum Preerythrocytic Antigens in Aotus lemurinus Monkeys
AUTOR(ES)
Perlaza, Blanca Liliana
FONTE
American Society for Microbiology
RESUMO
Aotus lemurinus monkeys were immunized with pools of either lipid-tailed peptides injected in PBS or peptides in Montanide ISA-51, all derived from four Plasmodium falciparum pre-erythrocytic antigens, namely, LSA1, LSA3, SALSA, and STARP. These formulations were well tolerated. Their immunogenicity was demonstrated by the induction of both B- and T-cell responses to most of the peptides studied (of the 12, 10 induced antibody production, 9 induced T-cell proliferative responses, and all 12 induced gamma interferon secretion). Immune responses proved to be long lasting, since some were still detectable 210 days after immunization. Of particular importance is the fact that B- and T-cell responses elicited in this way by synthetic peptides were specific for native parasite proteins on P. falciparum sporozoites and liver stage parasites.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=108363Documentos Relacionados
- Plasmodium falciparum: protein antigens identified by analysis of serum samples from vaccinated Aotus monkeys.
- Induction of protective immunity to monoclonal-antibody-defined Plasmodium falciparum antigens requires strong adjuvant in Aotus monkeys.
- Immunogenicity and Efficacy in Aotus Monkeys of Four Recombinant Plasmodium falciparum Vaccines in Multiple Adjuvant Formulations Based on the 19-Kilodalton C Terminus of Merozoite Surface Protein 1
- Immunization of Aotus monkeys with Plasmodium falciparum blood-stage recombinant proteins.
- Protective immunity induced in Aotus monkeys by recombinant SERA proteins of Plasmodium falciparum.