Immunoglobulin A-mediated hepatobiliary transport constitutes a natural pathway for disposing of bacterial antigens.
AUTOR(ES)
Russell, M W
RESUMO
The possibility that hepatobiliary transport of immunoglobulin A (IgA) immune complexes might eliminate bacterial antigens was investigated in mice with pneumococcal type III capsular polysaccharide and C carbohydrate and corresponding monoclonal antibodies. Although all isotypes of antibody caused uptake by the liver, only IgA, but not IgG or IgM, antibodies transported these substances into bile where they were detected in the form of immune complexes and as free antigens. Small doses (10 micrograms or less) of passively administered IgA antibody were sufficient to induce measurable transport of capsular polysaccharide into bile. Transport of C carbohydrate was significantly correlated with the level of naturally occurring IgA antibodies specific for the phosphocholine determinant, but not with IgM or IgG antibodies. These results suggest that the continual process of hepatic uptake of circulating polymeric IgA may function to eliminate bacterial macromolecular products that are not readily susceptible to other mechanisms of disposal.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=264405Documentos Relacionados
- Immunoglobulin A-Mediated Protection against Bordetella pertussis Infection
- Concanavalin A-mediated affinity film for Treponema pallidum.
- Reductive, Coenzyme A-Mediated Pathway for 3-Chlorobenzoate Degradation in the Phototrophic Bacterium Rhodopseudomonas palustris
- Epithelial cell polarization is a determinant in the infectious outcome of immunoglobulin A-mediated entry by Epstein-Barr virus.
- Replication protein A-mediated recruitment and activation of Rad17 complexes
