Immunohistochemical demonstration of choline acetyltransferase-immunoreactive preganglionic nerve fibers in guinea pig autonomic ganglia.
AUTOR(ES)
Lindh, B
RESUMO
The distribution of choline acetyltransferase (ChoAcTase)-like immunoreactivity in the superior cervical ganglion and the stellate ganglion was analyzed with immunohistochemistry. A dense network of ChoAcTase-immunoreactive nerve fibers was observed in both ganglia studied. The ChoAcTase-positive fibers were found in all parts of the ganglia but had a differential distribution, giving rise to a patchy staining pattern. After preganglionic denervation of the superior cervical ganglia, all ChoAcTase-positive fibers disappeared. For comparison, the distributions of enkephalin- and neuropeptide Y-like immunoreactivity were analyzed. In the stellate ganglion, the enkephalin-positive fibers had a marked regional distribution. Areas with the highest enkephalin-fiber density seemed to contain low numbers of ChoAcTase-positive fibers and vice versa. The findings give evidence for occurrence of acetylcholine synthesis in preganglionic fibers in paravertebral sympathetic ganglia.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=323942Documentos Relacionados
- Immunological regulation of synaptic transmission in isolated guinea pig autonomic ganglia.
- Properties of choline acetyltransferase isolated from squid ganglia.
- Electrical stimulation of preganglionic nerve increases tyrosine hydroxylase activity in sympathetic ganglia.
- Slow non-cholinergic excitatory potentials in neurones of the guinea-pig coeliac ganglia.
- Long-term facilitation of peptidergic transmission by catecholamines in guinea-pig inferior mesenteric ganglia.