Immunopharmacology of CpG Oligodeoxynucleotides and Ribavirin

AUTOR(ES)

Vollmer, Jörg

FONTE

American Society for Microbiology

RESUMO

To investigate their potential mechanisms of action, the nucleoside analogue ribavirin and a TLR9 agonist were compared. The CpG oligodeoxynucleotides (ODN) demonstrated strong TLR9-related Th1-type effects, and ribavirin appeared only to mediate signaling in TLR-transfected cells. CpG ODN represent a promising new type of therapeutic drug for hepatitis C or other infectious diseases.

Documentos Relacionados

• Adhesion- and migration-related side effects of phosphothioated CpG oligodeoxynucleotides
• CpG Oligodeoxynucleotides Enhance Host Defense during Murine Tuberculosis
• Immunomodulatory Effects of CpG Oligodeoxynucleotides on Established Th2 Responses
• CpG Oligodeoxynucleotides Improve the Survival of Pregnant and Fetal Mice following Listeria monocytogenes Infection
• Modulation of Airway Inflammation by Immunostimulatory CpG Oligodeoxynucleotides in a Murine Model of Allergic Aspergillosis