Importance of the bovine papillomavirus P2443 promoter in the regulation of E2 and E5 expression.
AUTOR(ES)
Spalholz, B A
RESUMO
The full-length bovine papillomavirus E2 gene product (E2TA), which has a direct role in DNA replication and functions as a transcriptional activator, can be expressed from an unspliced mRNA transcribed from the P2443 promoter or from spliced mRNAs transcribed from other upstream promoters. The regulation of E2 expression from these promoters is still in question. In the background of wild-type protein coding sequences, this study identified the P2443 promoter as the major source of E2TA as well as E5 expression in C127 cells.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=238053Documentos Relacionados
- The bovine papillomavirus P2443 promoter is E2 trans-responsive: evidence for E2 autoregulation.
- Characterization of the cis elements involved in basal and E2-transactivated expression of the bovine papillomavirus P2443 promoter.
- Differentiation-specific expression from the bovine papillomavirus type 1 P2443 and late promoters.
- Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming gene.
- Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein.
