Improving the Toolbox of Bioreductions by the Use of Continuous Flow Systems
AUTOR(ES)
Lopes, Raquel O., Grimm, Simon, Ribeiro, Joyce B., Leal, Ivana C. R., Miranda, Leandro S. M., Souza, Rodrigo O. M. A. de
FONTE
J. Braz. Chem. Soc.
DATA DE PUBLICAÇÃO
2015-03
RESUMO
Packed bed reactors can be used as an interesting alternative on the bioreduction of β-ketoesteres mediated by immobilized microorganisms. Here in, we report our results on the bioreduction of ethyl 3-oxohexanoate by immobilized Kluyveromyces marxianus cells and tert-butyl 3-oxobutanoate by immobilized Rhodotorula rubra cells under continuous flow conditions leading the desired β-hydroxy esters corresponding in high yields and enantiomeric excess.
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