In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases

AUTOR(ES)

Marshall, Kriste E

FONTE

BioMed Central

RESUMO

The identification of genes underlying complex traits has been aided by quantitative trait locus (QTL) mapping approaches, which in turn have benefited from advances in mammalian genome research. Most recently, whole-genome draft sequences and assemblies have been generated for mouse strains that have been used for a large fraction of QTL mapping studies. It has been shown here that strain-specific mouse genome sequence databases can be used as part of a high-throughput pipeline for the in silico discovery of gene-coding variations within murine QTLs.

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