In Vitro Activities of Linezolid against Important Gram-Positive Bacterial Pathogens Including Vancomycin-Resistant Enterococci
AUTOR(ES)
Noskin, Gary A.
FONTE
American Society for Microbiology
RESUMO
The emergence of resistance in gram-positive bacteria has necessitated a search for new antimicrobial agents. Linezolid is an oxazolidinone, a new class of antibacterial agents with enhanced activity against pathogens. We compared the activity of linezolid to those of other antimicrobial agents against 3,945 clinical isolates. Linezolid demonstrated potent activity against all isolates tested. For all vancomycin-susceptible enterococci, staphylococci, and streptococci, the activity of linezolid was comparable to that of vancomycin. Against oxacillin-resistant staphylococci and vancomycin-resistant enterococci, linezolid was the most active agent tested. In summary, linezolid appears to be a promising new antimicrobial agent for the treatment of gram-positive infections.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=89415Documentos Relacionados
- In vitro activity of ramoplanin against vancomycin-resistant gram-positive organisms.
- Activity of glycopeptides against vancomycin-resistant gram-positive bacteria.
- Activities of the semisynthetic glycopeptide LY191145 against vancomycin-resistant enterococci and other gram-positive bacteria.
- In vitro activities of daptomycin and other antimicrobial agents against vancomycin-resistant gram-positive bacteria.
- Recovery of vancomycin-resistant gram-positive cocci from children.
