In Vitro Antianaerobic Activity of Ertapenem (MK-0826) Compared to Seven Other Compounds

AUTOR(ES)

Hoellman, Dianne B.

FONTE

American Society for Microbiology

RESUMO

Ertapenem, imipenem, meropenem, ceftriaxone, piperacillin, piperacillin-tazobactam, clindamycin, and metronidazole were agar dilution MIC tested against 431 anaerobes. Imipenem, meropenem, and ertapenem were the most active β-lactams (MICs at which 50% of the strains are inhibited [MIC50s], 0.125 to 0.25 μg/ml; MIC90s, 1.0 to 2.0 μg/ml). Time-kill studies revealed that ertapenem at two times the MIC was bactericidal for 9 of 10 strains after 48 h. The kinetics for other β-lactams were similar to those of ertapenem.

Documentos Relacionados

• Antipneumococcal Activity of Ertapenem (MK-0826) Compared to Those of Other Agents
• Activity of Ertapenem (MK-0826) versus Enterobacteriaceae with Potent β-Lactamases
• In Vitro Activities of Ertapenem (MK-0826) against Recent Clinical Bacteria Collected in Europe and Australia
• In Vitro Activities of Ertapenem (MK-0826) against Clinical Bacterial Isolates from 11 North American Medical Centers
• Comparative In Vitro Activities of Ertapenem (MK-0826) against 469 Less Frequently Identified Anaerobes Isolated from Human Infections