In vitro antifungal activities of amphotericin B and liposome-encapsulated amphotericin B.
AUTOR(ES)
Hopfer, R L
RESUMO
The in vitro activities of liposome-encapsulated amphotericin B and free amphotericin B against Candida albicans 336 were comparable. Amphotericin B concentrations 12-fold and greater than 50-fold higher were required to kill the same organism when cholesterol and ergosterol were incorporated into the liposomes. The addition of cholesterol to liposomes caused a significant increase in the minimal fungicidal concentration of amphotericin B in 7 of 19 other yeast strains tested, whereas ergosterol caused an increase in 18 of the 19 strains.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=185527Documentos Relacionados
- Comparison of In Vitro Antifungal Activities of Free and Liposome-Encapsulated Nystatin with Those of Four Amphotericin B Formulations
- Prophylaxis of Candida albicans infection in neutropenic mice with liposome-encapsulated amphotericin B.
- Antileishmanial activity of liposome-encapsulated amphotericin B in hamsters and monkeys.
- Prophylaxis of Candida albicans Infection in Neutropenic Mice with Liposome-Encapsulated Amphotericin B
- Therapeutic evaluation of free and liposome-encapsulated amphotericin B in the treatment of systemic candidiasis in mice.
