In vitro antistreptococcal activity of the potassium-sparing diuretics amiloride and triamterene.
AUTOR(ES)
Giunta, S
RESUMO
The ionophore antimicrobial agents provide evidence that perturbations of the electrolyte balance of bacterial cells exert a growth-inhibitory activity. Several drugs acting on animal cell membranes have also been shown to be active on bacterial cells. In this paper, we report preliminary susceptibility studies showing that the class of potassium-sparing diuretics acting directly on monovalent cation fluxes on animal cells possesses a selective growth-inhibitory activity on hemolytic streptococci.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=180264Documentos Relacionados
- Effect of potassium-sparing diuretics on the renin-angiotensin-aldosterone system and potassium retention in heart failure.
- Effects of aldosterone and potassium-sparing diuretics on electrical potential differences across the distal nephron.
- Effect of amiloride on the intracellular sodium and potassium content of intact Streptococcus faecalis cells in vitro.
- Antistreptococcal Activity of Lactoperoxidase
- Use of amiloride as a potassium conserving agent in severe cardiac disease.