In Vitro Development of Resistance to Erythromycin, Other Macrolide Antibiotics, and Lincomycin in Mycoplasma pneumoniae
AUTOR(ES)
Niitu, Yasutaka
RESUMO
Mycoplasma pneumoniae was made highly resistant to erythromycin in vitro by serial subculture in broth media containing erythromycin. The resistance developed to erythromycin was 200 μg/ml with the Mac strain, a prototype of M. pneumoniae, and 10 μg/ml with the Fukumura strain, an isolate. The erythromycin resistance was accompanied by cross resistance to other macrolide antibiotics (leucomycin, josamycin, spiramycin, and oleandomycin) and to lincomycin, but there was no resistance to vernamycin B. Resistance to the antibiotics developed in vitro or in vivo was stable after the microorganisms were repeatedly transferred in antibiotic-free media.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=429004Documentos Relacionados
- Effects of rokitamycin and other macrolide antibiotics on Mycoplasma pneumoniae in L cells.
- Resistance of Group B Streptococcus to Selected Antibiotics, Including Erythromycin and Clindamycin
- Inactivation of the macrolide antibiotics erythromycin, midecamycin, and rokitamycin by pathogenic Nocardia species.
- Characterization of a Plasmid Determining Resistance to Erythromycin, Lincomycin, and Vernamycin Bα in a Strain of Streptococcus pyogenes
- Inducible and Constitutive Resistance to Macrolide Antibiotics and Lincomycin in Clinically Isolated Strains of Streptococcus pyogenes