In Vivo Acquisition of High-Level Resistance to Imipenem in Escherichia coli

AUTOR(ES)

Poirel, Laurent

FONTE

American Society for Microbiology

RESUMO

Four clonally related Escherichia coli strains were isolated successively from bile duct of a girl suffering from sclerosing cholangitis. One of them, selected after an imipenem-containing regimen, was resistant to carbapenems and to broad-spectrum cephalosporins due to a plasmid-mediated cephalosporinase, CMY-2, and the lack of outer membrane proteins OmpF and OmpC.

Documentos Relacionados

• Plasmid-mediated high-level resistance to erythromycin in Escherichia coli.
• High-level amikacin resistance in Escherichia coli due to phosphorylation and impaired aminoglycoside uptake.
• Association of two resistance mechanisms in a clinical isolate of Enterobacter cloacae with high-level resistance to imipenem.
• High-level expression of sperm whale myoglobin in Escherichia coli.
• Chromosomal Amplification of the Escherichia coli lipB Region Confers High-Level Resistance to Selenolipoic Acid