In vivo permeability of the human placenta to inulin and mannitol.
AUTOR(ES)
Bain, M D
RESUMO
1. Permeability of the term human placenta to inulin and mannitol was measured in six normal pregnancies. 2. Bolus and continuous infusion of inulin and mannitol to the mother for 1-2 h before delivery by Caesarean section achieved steady-state maternal serum concentrations. Net accumulation of inulin and mannitol in the fetus was measured by the subsequent neonatal urinary excretion. 3. Transplacental clearance was calculated by dividing the net flux by the time-averaged transplacental concentration gradient. Clearance for inulin was 0.86 +/- 0.1 ml min-1 (mean +/- S.E.M.) and for mannitol 7.3 +/- 0.8 ml min-1 (n = 6 in both cases).
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1191666Documentos Relacionados
- Permeability of the human placenta in vivo to four non-metabolized hydrophilic molecules.
- Expression of a bacterial mtlD gene in transgenic tobacco leads to production and accumulation of mannitol.
- Permeability of the fetal villous microvasculature in the isolated perfused term human placenta.
- PKQuest: capillary permeability limitation and plasma protein binding – application to human inulin, dicloxacillin and ceftriaxone pharmacokinetics
- COMPARISON OF THE VOLUME OF DISTRIBUTION, RENAL AND EXTRARENAL CLEARANCES OF INULIN AND MANNITOL IN MAN 1