In Vivo Resistance of a Laboratory-Selected Aspergillus fumigatus Isolate to Amphotericin B

AUTOR(ES)

Manavathu, Elias K.

FONTE

American Society for Microbiology

RESUMO

The fungal burdens (number of CFU per pair of lungs) in mice infected with Aspergillus fumigatus AB16.4 (for which the amphotericin B [AMB] MIC was elevated) and W73355 (drug-susceptible parent) were reduced by 21 and 81%, respectively, after 5 days of AMB treatment (2 mg/kg/day), indicating that AB16.4 also shows reduced susceptibility to AMB in a murine pulmonary aspergillosis model.

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