Inactivation of the elastase inhibitory activity of alpha 1 antitrypsin in fresh samples of synovial fluid from patients with rheumatoid arthritis.
AUTOR(ES)
Chidwick, K
RESUMO
The proteinase inhibitory ability of alpha 1 antitrypsin was measured in 23 samples of rheumatoid arthritis synovial fluid, eight osteoarthritic synovial fluids and nine normal control serum samples. For each sample a detailed kinetic analysis was performed with porcine pancreatic elastase as the target proteinase. Samples were stored for less than 24 hours at 4 degrees C before analysis, which does not significantly alter the proportion of inactive alpha 1 antitrypsin. In rheumatoid synovial fluid the elastase inhibitory ability was disproportionately depressed relative to the immunochemically determined concentrations of alpha 1 antitrypsin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1004581Documentos Relacionados
- Alpha 1-antitrypsin in serum and synovial fluid in rheumatoid arthritis.
- Receptor expression in synovial fluid neutrophils from patients with rheumatoid arthritis.
- Complement and immunoglobulins in synovial fluid from synovectomized patients with rheumatoid arthritis.
- Absence of Mycobacterium tuberculosis DNA in synovial fluid from patients with rheumatoid arthritis.
- Clonal heterogeneity of synovial fluid T lymphocytes from patients with rheumatoid arthritis.
