INCORPORATION OF 14C-TRYPTOPHAN INTO 14C-PROTEIN BY CULTURED RAT PINEALS: STIMULATION BY l-NOREPINEPHRINE*

AUTOR(ES)

Wurtman, Richard J.

RESUMO

Organ cultures of individual rat pineals incorporate 14C-tryptophan into proteins at a nearly constant rate for at least 48 hours. Previous studies have shown that these cultures also convert 14C-tryptophan to serotonin, melatonin, and 5-hydroxyindoleacetic acid, and release these indoles into the media. The formation of 14C-protein from 14C-tryptophan is accelerated by the addition to the culture medium of l-norepinephrine or related catecholamines but is not modified by serotonin, melatonin, or 5-hydroxyindoleacetic acid.

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