Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population
AUTOR(ES)
Lima, Magaly B.P.L.V., Oliveira-Filho, Aldemir Branco de, Campos, Júlia F., Melo, Fárida C.B.C., Neves, Washington Batista das, Melo, Raul Antônio Morais, Lemos, José Alexandre Rodrigues
FONTE
Genetics and Molecular Biology
DATA DE PUBLICAÇÃO
2009
RESUMO
Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis.
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