Increased Susceptibility of Secretor Factor Gene Fut2-Null Mice to Experimental Vaginal Candidiasis
AUTOR(ES)
Hurd, Elizabeth A.
FONTE
American Society for Microbiology
RESUMO
Fut2-LacZ-null mice, which are a model of the human ABO and Lewis nonsecretor group, display increased susceptibility to experimental yeast vaginitis, indicating a role for α(1,2)fucosylated cervical glycans in mucosal defense. However, the lack of significant effect of competitive inhibition by exogenous neoglycoproteins in this study emphasizes the complexity of Candida-epithelial cell adhesion events.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=427463Documentos Relacionados
- Fut2-null mice display an altered glycosylation profile and impaired BabA-mediated Helicobacter pylori adhesion to gastric mucosa
- Candida-Specific Antibodies during Experimental Vaginal Candidiasis in Mice
- Resistance of Congenitally Immunodeficient Gnotobiotic Mice to Vaginal Candidiasis
- Analysis of Vaginal Cell Populations during Experimental Vaginal Candidiasis
- Candida-specific Th1-type responsiveness in mice with experimental vaginal candidiasis.
