Increased urinary nitrate excretion in rats with adjuvant arthritis.
AUTOR(ES)
Stichtenoth, D O
RESUMO
OBJECTIVES--In rats with adjuvant arthritis measurements were taken of the urinary excretion of nitrate, reflecting endogenous nitric oxide (NO) formation, and cyclic guanosine monophosphate (cGMP). METHODS--Urinary nitrate was determined by gas chromatography, cGMP by radioimmunoassay. RESULTS--A significant (p < 0.001), more than three fold increase of urinary nitrate excretion was found in rats 20 days after induction of adjuvant arthritis compared with non-arthritic rats. There was no significant difference in urinary cGMP excretion between arthritic rats and control animals. CONCLUSION--The data suggest that the dramatic increase of urinary nitrate excretion is due to increase of NO synthesis by the inducible form of NO synthase.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1005398Documentos Relacionados
- Urinary nitrate excretion is increased in patients with rheumatoid arthritis and reduced by prednisolone.
- Blood lymphocyte subsets in rats with adjuvant arthritis.
- Urinary copper excretion in rheumatoid arthritis.
- Lysosomal enzyme activity in rats with adjuvant-induced arthritis.
- Decreased T-suppressor cell activity in rats with adjuvant arthritis.