Indirect spectrophotometric method for determination of captopril using Cr(VI) and diphenylcarbazide
AUTOR(ES)
Moldovan, Zenovia, Badea, Irinel Adriana, Bunaciu, Andrei A., Aboul-Enein, Hassan Y.
FONTE
Quím. Nova
DATA DE PUBLICAÇÃO
2012
RESUMO
A spectrophotometric method for the indirect determination of captopril (CP) in pharmaceutical formulations is proposed. The proposed procedure is based on the oxidation of captopril by potassium dichromate and the determination excess oxidant on the basis of its reaction with diphenylcarbazide (DPC). Under the optimum conditions, a good linear relationship (r = 0.9997) was obtained in the range of 0.08-3.5 µg mL-1. The assay limits of detection and quantitation were 0.024 and 0.08 µg mL-1, respectively. The results obtained for captopril determination in pharmaceuticals using the proposed method and those obtained with the US Pharmacopoeia method were in good agreement at the 95% confidence level.
Documentos Relacionados
- Evaluation of analytical procedures for determination of Cr(III and Cr(VI) in solid samples.
- Cr(VI) Reduction by Sulfidogenic and Nonsulfidogenic Microbial Consortia
- Estudo da redução de Cr(VI) por acido nitrico
- IN VITRO Cr(VI) SPECIATION IN SYNTHETIC SALIVA AFTER RELEASING FROM ORTHODONTIC BRACKETS USING SILICA-APTES SEPARATION AND GF AAS DETERMINATION
- Reduction of Cr(VI) by a Consortium of Sulfate-Reducing Bacteria (SRB III)