Induction of alpha/beta interferon and gamma interferon in mice infected with Listeria monocytogenes during pregnancy.
AUTOR(ES)
Nakane, A
RESUMO
Alpha/beta interferon (IFN-alpha/beta) was induced in the bloodstream of mice 48 h after intravenous infection with Listeria monocytogenes, whereas IFN-gamma was induced in the bloodstream 6 h after stimulation with specific antigen on day 5 of infection in virgin mice. In contrast, no IFN-alpha/beta or IFN-gamma was produced in the bloodstream of pregnant mice after L. monocytogenes infection. However, unusual acid-labile IFN-alpha/beta instead of IFN-gamma was produced in some of the pregnant mice in response to specific antigen. The bacterial growth in the organs of pregnant mice in the early stage of infection was normal, but resulted in the delay of T-cell-dependent elimination of bacteria from the organs of pregnant animals in the late stage, and numerous bacteria were detected in both the placenta and the fetus. The significance of the IFN system induced by L. monocytogenes infection in pregnant mice is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=261161Documentos Relacionados
- Impaired Antiviral Response and Alpha/Beta Interferon Induction in Mice Lacking Beta Interferon
- Promotion of Alpha/Beta Interferon Induction during In Vivo Viral Infection through Alpha/Beta Interferon Receptor/STAT1 System-Dependent and -Independent Pathways
- Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors.
- Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon.
- Role of interferon alpha/beta receptor chain 1 in the structure and transmembrane signaling of the interferon alpha/beta receptor complex.