Induction of c-Ha-ras transcription in rat cells by simian virus 40 large T antigen.

AUTOR(ES)

Segawa, K

RESUMO

Rat 3Y1 cells expressing simian virus 40 large T antigen under the control of the mouse mammary tumor virus long terminal repeat were established. The amount of c-Ha-ras mRNA in those cells was elevated by about 20 times in parallel with large T antigen after exposure to dexamethasone for 48 h. In chloramphenicol acetyltransferase assays with a plasmid containing the c-Ha-ras-1 promoter the increase in c-Ha-ras mRNA was shown to occur at the transcriptional level.

Documentos Relacionados

• Induction of c-Ha-ras gene expression by double-stranded RNA and interferon requirement.
• Initiation of transcription from the minute virus of mice P4 promoter is stimulated in rat cells expressing a c-Ha-ras oncogene.
• Analysis of simian virus 40 small t antigen-induced progression of rat F111 cells minimally transformed by large T antigen.
• Activation of simian virus 40 transcription in vitro by T antigen.
• Complementation by BCL2 and C-HA-RAS oncogenes in malignant transformation of rat embryo fibroblasts.