Induction of heat shock protein closely correlates with protection against Toxoplasma gondii infection.

AUTOR(ES)

Nagasawa, H

RESUMO

Heat shock proteins (HSPs) are evolutionarily highly conserved polypeptides that appear to be produced by many cells to preserve cellular functions under a variety of conditions of stress, including infections. We report that a 65-kDa HSP is present in mouse peritoneal cells that have been infected with a low-virulence (Beverley) strain of Toxoplasma gondii, as determined by electroblot assay using a monoclonal antibody specific for microbial HSP65. This HSP is, however, not expressed when infection occurs with the high-virulence RH strain of T. gondii. Furthermore, HSP was demonstrable in mice that acquired resistance against infection with a lethal dose of bradyzoites of the Beverley strain or even of an inoculum of a highly virulent strain of T. gondii (RH). From these results, it can be suggested that HSPs play an important role in developing effective defenses that include effective immune responses against infection with Toxoplasma parasites in vivo.

Documentos Relacionados

• Heat shock protein 88 and Aspergillus infection.
• Toxoplasma gondii–derived heat shock protein HSP70 functions as a B cell mitogen
• Complete Protection against Lethal Toxoplasma gondii Infection in Mice Immunized with a Plasmid Encoding the SAG1 Gene
• Dexamethasone protection of rat intestinal epithelial cells against oxidant injury is mediated by induction of heat shock protein 72.
• Role of beta interferon in resistance to Toxoplasma gondii infection.