Induction of L-phase variants of Nocardia caviae within intact murine lungs.
AUTOR(ES)
Beaman, B L
RESUMO
The data presented show that cells of Nocardia caviae 112 were converted to cell wall-deficient microbial variants within the intact murine lung after intranasal administration. At the time that these L-phase variants were recovered in large numbers from the lung, there was a correspondingly enhanced inflammation leading to alveolar consolidation and animal death. During the peak of this response (at 1 week after infection), normal nocardial cells were neither isolated from nor seen within the lung. It is suggested that the conversion of these normal nocardial cells to their L-phase variant leads to this extensive pulmonary damage. Furthermore, the L-phase organisms appear to play an active role in this pathological effect since introduction of similar amounts of killed nocardial cells into the lungs of the mice failed to produce a similar response.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=551102Documentos Relacionados
- Cell wall modification resulting from in vitro induction of L-phase variants of Nocardia asteroides.
- Viability of L-Phase Variants After Centrifugation
- INDUCTION BY ANTIBIOTICS AND COMPARATIVE SENSITIVITY OF L-PHASE VARIANTS OF STAPHYLOCOCCUS AUREUS
- Deoxyribonucleic Acid Base Compositions of Selected Mycoplasmas and L-Phase Variants
- Experimental Infection with Parent and L-Phase Variants of Neisseria meningitidis