Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis: role of CD4+ T cells in controlling larval development.

AUTOR(ES)

Al-Qaoud, K M

RESUMO

Litomosoides sigmodontis is the only filaria which develops from infective larvae into adults in immunocompetent laboratory mice. Depletion of CD4+ T cells from infected BALB/c mice resulted in worm and microfilarial burdens significantly higher than those of infected controls. Th2 cytokines, eosinophilia, and immunoglobulin E, which were strongly induced in infected controls, were diminished in CD4-depleted mice.

Documentos Relacionados

• Expansion of gamma delta+ T cells in BALB/c mice infected with Leishmania major is dependent upon Th2-type CD4+ T cells.
• An avirulent lipophosphoglycan-deficient Leishmania major clone induces CD4+ T cells which protect susceptible BALB/c mice against infection with virulent L. major.
• Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility
• The changes of CD4+CD25+/CD4+ proportion in spleen of tumor-bearing BALB/c mice
• Clonal Expansion of Antigen-Specific CD4 T Cells following Infection with Salmonella typhimurium Is Similar in Susceptible (Itys) and Resistant (Ityr) BALB/c Mice