Infinite allele model with varying mutation rate.
AUTOR(ES)
Nei, M
RESUMO
Available data suggest that the variation in mutation rate among protein loci follows the gamma distribution. Thus, taking into account this variation, formulae are developed for the distribution of allele frequencies, mean and variance of heterozygosity, expected number of alleles, proportion of polymorphic loci, and genetic distance. These formulae should be more appropriate for the analysis of gene frequency data for protein loci than equivalent formulae with constant mutation rate.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=431369Documentos Relacionados
- Twenty-Five Years Ago in Genetics: The Infinite Allele Model
- 5-Azacytidine and RNA secondary structure increase the retrovirus mutation rate.
- The Sampling Distribution of Linkage Disequilibrium under an Infinite Allele Model without Selection
- The antiretrovirus drug 3'-azido-3'-deoxythymidine increases the retrovirus mutation rate.
- Changes in transmitral velocities with heart rate.