Influence of experimental rat model of multiple organ dysfunction on cefepime and amikacin pharmacokinetics.

AUTOR(ES)

Mimoz, O

RESUMO

We adapted an experimental model of multiple organ dysfunction to study the alterations it induces in the pharmacology of cefepime and amikacin. The half-lives of both antibiotics were significantly prolonged because of nonsignificant enhancement of the volume of distribution and reduced renal elimination. In the presence of multiple organ dysfunction, the concentration of each antibiotic in the lungs, compared with that in the lungs of healthy controls, was significantly decreased, despite similar concentrations in plasma, indicating that the application of a standard antibiotic concentration in plasma could lead to underdosage in tissues during the initial days of therapy.

Documentos Relacionados

• Influence of rifampin on fleroxacin pharmacokinetics.
• Multiple-dose pharmacokinetics of amikacin and ceftazidime in critically ill patients with septic multiple-organ failure during intermittent hemofiltration.
• Effect of lomefloxacin on theophylline pharmacokinetics.
• Effect of age and renal function on cefonicid pharmacokinetics.
• Antacids and ciprofloxacin pharmacokinetics.