Influence of operational variables on properties of piroxicam pellets prepared by extrusion-spheronization: A technical note

AUTOR(ES)

Sinha, Vivek R.

FONTE

Springer-Verlag

RESUMO

The processing conditions has a pronounced effect on the pellet properties. Drying conditions influenced the mean size and the drug release of the pellets. Because of the shrinking of the pellets upon drying at higher temperatures, the pellets also showed increased densities. Freeze drying almost prevented shrinking and thus led to the highest drug release. With an increase in the temperature of drying, the drug release rate decreased.

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