Influence of renal denervation on blood pressure, sodium and water excretion in acute total obstructive apnea in rats
AUTOR(ES)
Franquini, J.V.M., Medeiros, A.R.S., Andrade, T.U., Araújo, M.T.M., Moysés, M.R., Abreu, G.R., Vasquez, E.C., Bissoli, N.S.
FONTE
Brazilian Journal of Medical and Biological Research
DATA DE PUBLICAÇÃO
2009-02
RESUMO
Obstructive apnea (OA) can exert significant effects on renal sympathetic nerve activity (RSNA) and hemodynamic parameters. The present study focuses on the modulatory actions of RSNA on OA-induced sodium and water retention. The experiments were performed in renal-denervated rats (D; N = 9), which were compared to sham (S; N = 9) rats. Mean arterial pressure (MAP) and heart rate (HR) were assessed via an intrafemoral catheter. A catheter was inserted into the bladder for urinary measurements. OA episodes were induced via occlusion of the catheter inserted into the trachea. After an equilibration period, OA was induced for 20 s every 2 min and the changes in urine, MAP, HR and RSNA were recorded. Renal denervation did not alter resting MAP (S: 113 ± 4 vs D: 115 ± 4 mmHg) or HR (S: 340 ± 12 vs D: 368 ± 11 bpm). An OA episode resulted in decreased HR and MAP in both groups, but D rats showed exacerbated hypotension and attenuated bradycardia (S: -12 ± 1 mmHg and -16 ± 2 bpm vs D: -16 ± 1 mmHg and 9 ± 2 bpm; P < 0.01). The basal urinary parameters did not change during or after OA in S rats. However, D rats showed significant increases both during and after OA. Renal sympathetic nerve activity in S rats increased (34 ± 9%) during apnea episodes. These results indicate that renal denervation induces elevations of sodium content and urine volume and alters bradycardia and hypotension patterns during total OA in unconscious rats.
Documentos Relacionados
- Oral administration of L-arginine decreases blood pressure and increases renal excretion of sodium and water in renovascular hypertensive rats
- Effect of inhibition of nitric oxide synthase on blood pressure and renal sodium handling in renal denervated rats
- Influence of age, systemic blood pressure, smoking, and blood viscosity on orbital blood velocities.
- THE EFFECT OF RENAL DENERVATION ON THE LEVEL OF ARTERIAL BLOOD PRESSURE AND RENAL FUNCTION IN ESSENTIAL HYPERTENSION
- Comparison of the effects of continuous positive airway pressure, oral appliance and exercise training in obstructive sleep apnea syndrome