Influence of Renal Failure on Intestinal Clearance of Ciprofloxacin in Rats
AUTOR(ES)
Dautrey, Sophie
FONTE
American Society for Microbiology
RESUMO
Following intravenous doses, ciprofloxacin pharmacokinetics in control and nephrectomized rats were studied. There were no differences between control and nephrectomized rats for area under the concentration-time curve in plasma or biliary clearance. The intestinal clearance of ciprofloxacin was increased in nephrectomized rats. Intestinal elimination seems to compensate partially for the decrease in urinary excretion of ciprofloxacin in nephrectomized rats.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=89180Documentos Relacionados
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