Influencia das proteinas de soro de leite bovino no estado nutricional, composição corporal e sistema imune em coorte de crianças com Sindrome da Imunodeficiencia Adquirida (AIDS)

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

HIV-1 infected children rise special concem about their nutritional and health status, due to immunosuppressive effects of the infection. The development of strategies for the recovery of the nutritional status and enhancement of the immune system is of great interest for immunodepressed patients. Nutritional supplementation with whey proteins is recognized as stimulating the immune system toward an increase of glutathione synthesis. The levels of this antioxidant are reduced in some HIV-1 infected individuaIs and are correlated with disease progression. With the objective of investigating the influence of a whey protein concentrate on the nutritional status body composition, innate and adaptative immune system in a cohort of children with AIDS, a prospective double-blind clinical trial with 18 children, between 1 and 6 years of age was conduced. During the experiment, children received whey protein or placebo (maltodextrin) for 4 months. The nutritional status was assessed by weight gain, growth and food intake. Midarm circumference, skinfold thickness and bioelectrical impedance were used to determine body composition. Influence on immune system was evaluated by erythrocyte glutathione levels, reactive oxygen species release, T lymphocytes counts (CD4+and CD8+) and occurrence of associated infections. Data were submitted to statistical analysis. Whey proteins did not influence nutritional status or body composition, but a modulation on the glutathione synthesis, a trend for improvement on CD4+/CD8+ ratios and reduction of infectious episodes were observed. The data suggested that whey proteins modulate the immune system by the increase of the erythrocyte glutathione synthesis and reduction of the opportunistic episodes

ASSUNTO(S)

proteinas aids (doença) em crianças pediatria

ACESSO AO ARTIGO

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