Inhibition by itaconate of growth of methylotrophic bacteria.

AUTOR(ES)

Bellion, E

RESUMO

The effects of the isocitrate lyase-directed growth inhibitor itaconate on the growth of certain methylotrophic organisms was investigated. It was found that growth of those organisms possessing the Icl(+)-serine pathway of one-carbon metabolism was inhibited during growth on methylamine and on acetate, but not on glucose. Organisms possessing the Icl(-)-serine pathway pathway were unaffected. Organism PAR, an Icl(-)-serine pathway type, was not specifically inhibited during growth on acetate. This finding further substantiates previous reports of the lack of isocitrate lyase in this organism, indicating a totally new pathway for acetate assimilation.

Documentos Relacionados

• Phylogenetic analysis and development of probes for differentiating methylotrophic bacteria.
• Growth inhibition of Streptococcus mutans by cellular extracts of human intestinal lactic acid bacteria.
• Use of oligodeoxynucleotide signature probes for identification of physiological groups of methylotrophic bacteria.
• Microbial oxidation of gaseous hydrocarbons: epoxidation of C2 to C4 n-alkenes by methylotrophic bacteria.
• Pattern of organotin inhibition of methanogenic bacteria.