Inhibition by secalonic acid D of oxidative phosphorylation and Ca2+-induced swelling in mitochondria isolated from rat livers.
AUTOR(ES)
Kawai, K
RESUMO
The in vitro biological activity of secalonic acid D, a mycotoxin from Aspergillus ochraceus, was studied to assess its cytotoxicity for isolated rat liver mitochondria. Secalonic acid D uncoupled the oxidative phosphorylation of mitochondria and caused a mild inhibition of state 3 respiration. Secalonic acid D weakly enhanced latent ATPase activity in mitochondria but suppressed 2,4-dinitrophenol-stimulated ATPase activity. Secalonic acid D did not induce pseudoenergized swelling of mitochondria and markedly inhibited the Ca2+-induced swelling of mitochondria in KCl isotonic solution.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=239469Documentos Relacionados
- Tirandamycin: Inhibition of Oxidative Phosphorylation in Rat Liver Mitochondria
- Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin
- Mitochondrial Ca2+-induced Ca2+ Release Mediated by the Ca2+ Uniporter
- Visualization of Ca2+-induced phospholipid domains.
- Uncoupling of oxidative phosphorylation in rat liver mitochondria by general anesthetics.