Inhibition of aminoglycoside activity in heparin.

AUTOR(ES)

Nilsson, L

RESUMO

Measurements of aminoglycosides by an agar disk diffusion assay are inhibited by heparin in a dose-dependent way. When assayed by a homogeneous immunoassay, this was only evident for tobramycin. This indicates that specimens for aminoglycoside measurement should not be obtained in heparinized tubes. When heparin is used clinically as an anticoagulant, the amount in blood does not reach levels that affect the aminoglycoside activity.

Documentos Relacionados

• Inhibition of factor 13 by heparin.
• Inhibition of human immunodeficiency virus gene amplification by heparin.
• Structure of the antithrombin-binding site in heparin.
• Analytical accuracy of determinations of aminoglycoside concentrations by enzyme multiplied immunoassay, fluorescence polarization immunoassay, and radioimmunoassay in the presence of heparin.
• Heparin. Chemistry and Clinical Usage