Inhibition of bacteriophage PBS2 replication in Bacillus subtilis by phleomycin.
AUTOR(ES)
Post, L
RESUMO
Phleomycin is an effective inhibitor of the replication of Bacillus subtilis bacteriophage PBS2, whose DNA contains uracil instead of thymine. Phleomycin does not affect the induction of the known phage enzymes involved in deoxyribonucleotide metabolism. But phage DNA synthesis is severely inhibited by phleomycin, and late virion protein synthesis is eliminated. These effects appear to result from a phleomycin-induced degradation of the parental phage DNA. Similar inhibitory and degradative effects on DNA are seen in phleomyinc-treated, uninfected cells. This system is unaffected by the related antibiotic, bleomycin.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=354461Documentos Relacionados
- Bacteriophage transformation of PBS2 in Bacillus subtilis.
- New Deoxyribonucleic Acid Polymerase Induced by Bacillus subtilis Bacteriophage PBS2
- Rifampicin-resistant bacteriophage PBS2 infection and RNA polymerase in Bacillus subtilis
- Effect of Nalidixic Acid on PBS2 Bacteriophage Infection of Bacillus subtilis
- Metabolism of uracil-containing DNA: degradation of bacteriophage PBS2 DNA in Bacillus subtilis.