Inhibition of Epstein-Barr virus-mediated capping of CD21/CR2 by alpha interferon (IFN-alpha): immediate antiviral activity of IFN-alpha during the early phase of infection.
AUTOR(ES)
Delcayre, A X
RESUMO
Early events of human B-lymphocyte infection by Epstein-Barr virus involve the virus binding to CD21, capping, and subsequent internalization of the virus-receptor complex. We show here that alpha interferon (IFN-alpha) inhibits the capping of Epstein-Barr virus-CD21 complexes. Synthetic peptides with the CD21 binding motif of IFN-alpha mimic IFN-alpha activity, suggesting that this effect may be mediated by IFN-alpha-CD21 interaction. Our findings demonstrate a novel and immediate mechanism of IFN-alpha action.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=237619Documentos Relacionados
- Soluble recombinant CR2 (CD21) inhibits Epstein-Barr virus infection.
- The EBNA2 Polyproline Region Is Dispensable for Epstein-Barr Virus-Mediated Immortalization Maintenance
- Antiherpetic effects of a human alpha interferon analog, IFN-alpha Con1, in hamsters.
- Differential splicing of Epstein-Barr virus immediate-early RNA.
- Structure and expression of cloned murine IFN-alpha genes.
