INHIBITION OF OXIDATIVE PHOSPHORYLATION IN ESCHERICHIA COLI BY DIHYDROSTREPTOMYCIN
AUTOR(ES)
Bragg, P. D.
RESUMO
Bragg, P. D. (University of British Columbia, Vancouver, B.C., Canada), and W. J. Polglase. Inhibition of oxidative phosphorylation in Escherichia coli by dihydrostreptomycin. J. Bacteriol. 86:1236–1240. 1963.—Dihydrostreptomycin inhibited the oxidation of succinate in extracts of antibiotic-sensitive Escherichia coli. The inhibitable reaction required both the particulate and the supernatant fractions from sonic extracts which had been centrifuged at 100,000 × g. Dihydrostreptomycin was found to inhibit phosphorylation coupled with the oxidation of reduced nicotinamide adenine dinucleotide (NADH). The inhibition of oxidative phosphorylation by dihydrostreptomycin appeared to precede the effect of the antibiotic on oxidation. The streptomycin antagonist, 2-heptyl-4-hydroxyquinoline N-oxide, inhibited the oxidation of succinate and of NADH, but showed little effect on oxidative phosphorylation. Oxidative phosphorylation was not affected by dihydrostreptomycin in strains of E. coli which were antibiotic-resistant or -dependent.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=283635Documentos Relacionados
- DIHYDROSTREPTOMYCIN, VITAMIN K2-COUPLED TETRAZOLIUM REDUCTION, AND OXIDATIVE PHOSPHORYLATION IN ESCHERICHIA COLI
- INHIBITION OF THE ANAEROBIC PYRUVATE DISSIMILATION IN ESCHERICHIA COLI BY DIHYDROSTREPTOMYCIN1
- INHIBITION OF THE ANAEROBIC PYRUVATE METABOLISM OF ESCHERICHIA COLI BY DIHYDROSTREPTOMYCIN, , 123
- EFFECT OF DIHYDROSTREPTOMYCIN ON ESCHERICHIA COLI
- EFFECT OF CARBON DIOXIDE AND AGING ON THE DIHYDROSTREPTOMYCIN INHIBITION OF PYRUVATE FERMENTATION IN ESCHERICHIA COLI1
