Inhibition of Poxvirus Maturation by Rifamycin Derivatives and Related Compounds
AUTOR(ES)
Pennington, T. H.
RESUMO
The effect of a number of rifamycin derivatives and related compounds on the reversibility of the rifampin-induced virus maturation block was studied by using BHK-21 cells infected with vaccinia virus. All of the derivatives of 3-formyl rifamycin SV maintained this block, the required concentration varying from 100 to 1,000 μg/ml. These compounds vary only in the nature of the side-chain attached to the 3C atom on the naphthohydroquinone moiety; no obvious correlation between the nature of this side-chain and antiviral activity was found. Streptovaricin complex and tolypomycin R also maintained the maturation block; tolypomycin also produced marked alterations in the appearance of the viroplasm contained in rifampin-induced inclusions and immature virus particles.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=356202Documentos Relacionados
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