Inhibition of Rous sarcoma virus replication by antisense RNA.
AUTOR(ES)
Chang, L J
RESUMO
Previous results have indicated that Rous sarcoma virus env gene expression is specifically inhibited by antisense RNA (L.-J. Chang and C. M. Stoltzfus, Mol. Cell. Biol. 5:2341-2348, 1985). In this study, we compare the extents of inhibition by antisense RNA derived from different parts of the Rous sarcoma virus genome, and we show that antisense constructs containing the 3'-end noncoding region inhibit env expression to a similar extent as those containing the 5'-end noncoding region or coding region. Furthermore, we show that antisense RNA inhibits virus replication at other levels in addition to translation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=254039Documentos Relacionados
- Inhibition of retroviral replication by anti-sense RNA.
- Terminal redundancy and the origin of replication of Rous sarcoma virus RNA.
- Physical properties of Rous Sarcoma Virus RNA.
- Gene expression from both intronless and intron-containing Rous sarcoma virus clones is specifically inhibited by anti-sense RNA.
- Structure-function relationship of Rous sarcoma virus leader RNA.