Inhibition of Sterol Biosynthesis by Bacitracin
AUTOR(ES)
Stone, K. John
RESUMO
Bacitracin is an inhibitor of the biosynthesis of squalene and sterols from mevalonic acid, C5-isopentenyl pyrophosphate, or C15-farnesyl pyrophosphate catalyzed by preparations from rat liver. The antibiotic is active at extremely low ratios of antibiotic to substrate. The mechanism of inhibition appears to be the formation of a complex between bacitracin, divalent cation, and C15-farnesyl pyrophosphate and other isoprenyl pyrophosphates. It is similar to the formation of the complex with C55-isopropenyl pyrophosphate in microbial systems. The toxicity of bacitracin for animal cells could be due in part to the formation of these complexes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=426683Documentos Relacionados
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