Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis.

AUTOR(ES)

Yokota, T

RESUMO

By using an assay system based on a human hepatoblastoma cell line (HB611) that continuously synthesizes hepatitis B virus DNA, the following compounds were found to inhibit hepatitis B virus DNA synthesis at concentrations that were significantly lower than their minimum cytotoxic concentrations: 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP), (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine, 9-(phosphonylmethoxyethyl)adenine, 2',3'-dideoxy-2',3'-didehydrocytidine, and 2',3'-dideoxycytidine. The most potent compound was PMEDAP (50% effective concentration, 0.02 micrograms/ml). The selective index, or ratio of the 50% cytotoxic concentration to 50% effective concentration, of PMEDAP was greater than 750.

Documentos Relacionados

• Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis.
• Inhibitory effects of antiviral compounds on respiratory syncytial virus replication in vitro.
• Precore-mediated inhibition of hepatitis B virus progeny DNA synthesis.
• Effects of mutations within and adjacent to the terminal repeats of hepatitis B virus pregenomic RNA on viral DNA synthesis.
• Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture.