Initiation of Deoxyribonucleic Acid Replication in Escherichia coli B/r: Chronology of Events and Transcriptional Control of Initiation
AUTOR(ES)
Messer, Walter
RESUMO
Three processes necessary for the initiation of deoxyribonucleic acid replication have been separated in time in synchronously growing Escherichia coli B/r. One can be inhibited with 2 μg of chloramphenicol per ml and occurs about 20 min prior to initiation. A second step, occurring 5 to 10 min prior to initiation, is sensitive to 4 to 30 μg of chloramphenicol per ml. A third process occurs at the time of initiation and can be inhibited with rifampin. The experiments suggest that transcription itself, or the synthesis of a relatively small ribonucleic acid, is required for initiation of replication.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=251374Documentos Relacionados
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