Insensitivity of activation delays in potassium and sodium channels to heavy water in Myxicola giant axons.
AUTOR(ES)
Schauf, C L
RESUMO
Substitution of heavy water (D2O) for H2O slows the Na+ and K+ currents in Myxicola giant axons by 40-50% at 5 degrees C. In contrast, the delays in Na+ K+ activation which can be produced by hyperpolarizing pre-pulses are not affected by solvent substitution. We suggest that in the cascade of transitions leading to the opening of Na+ and K+ channels, D2O affects only the final step that establishes the aqueous pore across the membrane.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1199101Documentos Relacionados
- Gallamine triethiodide-induced modifications of sodium conductance in Myxicola giant axons.
- Synthesis of sodium channels in the cell bodies of squid giant axons.
- The effect of external potassium on the removal of sodium inactivation in squid giant axons.
- Changed distribution of sodium channels along demyelinated axons.
- Activation of internodal potassium conductance in rat myelinated axons.