Insomnia and Polymorphisms in hypocretin receptors: search for association in a Brazilian population sample. / Busca de associações de polimorfismos nos receptores de hipocretina com fenótipos do sono em voluntários sadios e insones da cidade de São Paulo.

AUTOR(ES)

Lhoyane de Moraes Oliveira

DATA DE PUBLICAÇÃO

2008

RESUMO

Hypocretin system has been described as one of the more important neurotransmission system to be involved in the waking process. Lack of function of this system, by mutations or neuron death, leads to pronounced excessive sleepiness in mammals. It is proposed that a hyperactive hypocretin system can result in hyper arousal episodes and insomnia. The hypocretins 1 and 2 bind to two known receptors widely distributed in the brain. In the present we sought to analyze whether polymorphisms in both receptors 1 and 2 are associated with insomnia. We have enrolled 83 insomnia patients, confirmed the complain with polysomnographic recordings and compared the frequencies of the hypocretins receptors polymorphisms with healthy controls with no sleep disorder confirmed by two nights of sleep recording. Our results show no association of any of the polymorphisms in both receptors with insomnia.

ASSUNTO(S)

insônia - genética receptores de neurotransmissor - hipocretina polimorfismo genético psicobiologia

Documentos Relacionados

• Incidence of thin membrane nephropathy: morphometric investigation of a population sample.
• Arterial blood pressures and hypertension in an urban African population sample.
• Análise de Polimorfismos do Gene MC1R Associados a Fenótipos Humanos de Pigmentação na População Brasileira.
• Influence of genetic polymorphisms on the childhood
• Prevalence of overweight and obesity among adult subjects of an urban African population sample.