INSULIN BIOSYNTHESIS IN THE RAT: DEMONSTRATION OF TWO PROINSULINS*
AUTOR(ES)
Clark, Jeffrey L.
RESUMO
Proinsulin, a single-chain precursor of insulin, has been detected in biosynthetic studies in vitro,1-4 and in crystalline preparations of insulin from several species.1, 5-7 It appears that proinsulin normally serves neither as a major storage nor secretory form of the hormone.8 Its primary functions seems to be to facilitate the efficient formation of the disulfide bonds of insulin.9
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=285984Documentos Relacionados
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