Insulin‐degrading enzyme is genetically associated with Alzheimer's disease in the Finnish population
AUTOR(ES)
Vepsäläinen, Saila
FONTE
BMJ Group
RESUMO
The gene for insulin‐degrading enzyme (IDE), which is located at chromosome 10q24, has been previously proposed as a candidate gene for late‐onset Alzheimer's disease (AD) based on its ability to degrade amyloid β‐protein. Genotyping of single nucleotide polymorphisms (SNPs) in the IDE gene in Finnish patients with AD and controls revealed SNPs rs4646953 and rs4646955 to be associated with AD, conferring an approximately two‐fold increased risk. Single locus findings were corroborated by the results obtained from haplotype analyses. This suggests that genetic alterations in or near the IDE gene may increase the risk for developing AD.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=2597950Documentos Relacionados
- Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster.
- Structural changes in intermediate filament networks alter the activity of insulin-degrading enzyme
- Cellular distribution of insulin-degrading enzyme gene expression. Comparison with insulin and insulin-like growth factor receptors.
- Direct measurement of proinsulin in human plasma by the use of an insulin-degrading enzyme
- Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo