Integrating with integrins.

AUTOR(ES)

Schwartz, M A

RESUMO

Our central claim is that signaling by integrins provides a mechanism by which signals generated in response to adhesion, soluble hormones, and mechanical forces can interact. Such interactions permit cells to integrate these different classes of external stimuli and hence to orchestrate an efficient response. This integrating function of integrins is likely to be essential for much of development and physiology, as well as complex pathologies such as cancer. Understanding in detail how these signals are transduced and processed is likely to be an important area of research in the near future.

Documentos Relacionados

• Integrins.
• Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins.
• Cell adhesion to extracellular matrix regulates the life cycle of integrins.
• Leukocyte adhesion deficiency type 1 (LAD-1)/variant. A novel immunodeficiency syndrome characterized by dysfunctional beta2 integrins.
• Fibronectin receptor functions in embryonic cells deficient in alpha 5 beta 1 integrin can be replaced by alpha V integrins.