Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway
AUTOR(ES)
Schell, Thomas
FONTE
BioMed Central
RESUMO
When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA caps are key effectors of the fate of spliced mRNAs and may regulate whether mRNAs containing premature stop codons are degraded.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=139025Documentos Relacionados
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