Interaction of endostatin with integrins implicated in angiogenesis
AUTOR(ES)
Rehn, Marko
FONTE
The National Academy of Sciences
RESUMO
Endostatin, a fragment of collagen XVIII, is a potent antagonist of angiogenesis and inhibitor of tumor growth in mouse models. At present, the mechanism of action of endostatin is unknown. We show here that recombinantly produced human endostatin interacts with α5- and αv-integrins on the surface of human endothelial cells. We further demonstrate that the endostatin–integrin interaction is of functional significance in vitro, as we found that immobilized endostatin supports endothelial cell survival and migration in an integrin-dependent manner. Soluble endostatin in turn inhibits integrin-dependent endothelial cell functions, such as cell migration. Taken together, these results implicate integrins as potential targets for endostatin function and support the importance of integrins in endothelial cell biology and angiogenesis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=14702Documentos Relacionados
- Molecular Interplay between Endostatin, Integrins, and Heparan Sulfate*
- Endothelial integrins and angiogenesis: not so simple anymore
- The First Draft of the Endostatin Interaction Network*
- Intersubunit signal transmission in integrins by a receptor-like interaction with a pull spring
- Human tumstatin and human endostatin exhibit distinct antiangiogenic activities mediated by αvβ3 and α5β1 integrins
